Identification of Phase I & Phase II Metabolites of Maca Constituents
نویسنده
چکیده
Maca (Lepidium meyenii Walpers) is a plant cultivated in central Peru, and its root is a common active ingredient in the botanical dietary supplements for its effects on a variety of health issues such as sexual dysfunction, anemia, and cancer. The plant contains compounds that have cytotoxic and antioxidant activities, but information on the metabolism of the bioactive compounds is limited. The goal of this study was to identify Phase I and Phase II metabolites of the bioactive constituents of maca extracts, such as induction and inhibition of CYP3A4 and their interactions with anticancer drugs, for further study.
منابع مشابه
N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES
The new phase-II N-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. The identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). It was found that the butobarbitone N-glucoside comprised 26% of the dos...
متن کاملIdentification and determination of phase II nabumetone metabolites by high-performance liquid chromatography with photodiode array and mass spectrometric detection.
Chromatographic analyses play an important role in the identification and determination of phase I and phase II drug metabolites. While the chemical standards of phase I metabolites are usually available from commercial sources or by various synthetic, degradation or isolation methods, the phase II drug metabolites have usually more complicated structures, their standards are in general inacces...
متن کاملGender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to CYP2D6 Phenotype in Iranian Population
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ...
متن کاملGender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to CYP2D6 Phenotype in Iranian Population
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ...
متن کاملPhase II monitoring of multivariate simple linear profiles with estimated parameters
In some applications of statistical process monitoring, a quality characteristic can be characterized by linear regression relationships between several response variables and one explanatory variable, which is referred to as a “multivariate simple linear profile.” It is usually assumed that the process parameters are known in Phase II. However, in most applications, this assumption is viola...
متن کامل